Osteogenesis imperfecta (OI) is a rare genetic disease that affects type I collagen.
90% of the cases are caused by COL1A1 or COL1A2 mutations.
The main symptom is bone fragility and although skin is also a collagen I rich tissue it is only slighlty affected by the disease.
This project has 2 main goals:
- To study the biomechanical response of fibroblasts and osteoblasts with OI mutations.
- To study biomechanical correlations between skin and bones in OI: can the skin be an indicator of bone degradation?
We will achieve this in 3 steps:
- Development of mineralized and connective 3D bioprinted functional tissues.
- Induction of Osteogenesis imperfecta within in-vitro functional tissues. Assessment of the mechanisms of mechano-transduction in-situ.
- Mediation of the structural and functional properties of collagen fibrils in response to environmental and mechanical confinement.
Partners : Ecole Centrale de Lyon, HCL, LabSkin Creations