Tissue engineering strategies often rely on the homogenous distribution of cells throughout a biomaterial scaffold, resulting in tissues of homogeneous composition and lacking the complexity of their native counterparts. Besides, micro-tissues formed by maturation of aggregated cells can be used as building blocks, generating tissues with composition and architecture mimicking native tissues. For example, theses micro-tissues can be assembled into an organized array of polymeric chambers whose function is to support the growth of cellular aggregates and provide mechanical reinforcement to the resulting tissues.
At the 3d.FAB plateform we are
- Developping a python-based software for automated localization and morphological analysis of micro-tissues
- Developping microfluidic assays for mechanical characterization of micro-tissues
- Collaborating with academic team and private companies who developped tools for spatial paterning of micro-tissues