The aim of the project is to develop and optimize a bioreactor process for connective tissue maturation and vascularization. Based on Computational Flow Dynamic (CFD) simulations, specific bioreactors were designed to create optimal liquid flow inside the 3D printed tissues for nutrient and oxygen renewal as well as stimulation of cell proliferation, extracellular matrix secretion and microvascularization.

Partenaires : Sartorius