New self-healing support medium for 3D printing of soft materials

SIn the medical field, 3D printing using material deposition present limitations on printing soft materials from fluids, like silicones. 3D printing in support medium (FRESH) overcome these limits with the holding of the printed material, without collapse, during its liquid-solid transition. The success of this technique relies on the rheological properties of the support medium, which needs to be tailored and understood, thus enabling its self-healing during the process while holding the printed shape.

                In this study, we developed a new approach which enables the tailoring of the static yield stress of the poloxamer 407 hydrogel used as a support medium for 3D printing thanks to the addition of poly(ethylene glycol) (PEG). In order to understand and determine the strengths of this self-healing support medium, rheological measurements and 3D printing were performed. Poloxamer hydrogels forms by micelles entanglement. Here, adding the PEG disturbs this entanglement by dehydration of the hydrophilic parts of the polymer due to the salting-out effect. This enables a precise control of the static yield stress of the hydrogel and an easier printing of fluid materials by material deposition.

                To demonstrate the strength of this technique, an anatomical shape, a mitral valve, was 3D printed from a fluid material. Furthermore, the understanding of structure-properties relations of the poloxamer 407 hydrogels allow us to extend this technique in the bioprinting field to answer the challenges of regenerative and personalized medicine.

FingerMap: predict printability of soft materials is now possible!

The experience of our 3d.FAB platform in 3D printing allow us to imagine a new approach to predict printability of soft material. From STL file of a 3D object, a « FingerMap » is developed then compared to material properties, to evaluate potential collapse of the object in printing process. This predictive tool appear as a new idea to make easier the 3d printing of soft material through Liquid Deposition Modeling technique.

Ultra-high resolution 3D printing system: The uFAB-3D printer!

µFAB-3D is a ultra-high resolution 3D-printing system, based on two-photon polymerization direct laser writing technology. With a minimal feature size down to 0.2microns-wide, µFAB-3D opens new perspectives in microfluidics, micro-optics, cells culture, micro-robotics or meta-materials.

The printer is compatible with a wide range of materials which enables it to be used in many different areas. For more informations visit the company’s website: http://www.microlight.fr/uFAB.html

We are currently using this technology to create self-assembling 3D micro-objects and to 3D print dermal-epidermal junction model compatible with a reconstructed skin culture (See pictures below).

MIT Grand Hack, Paris

Over the three proposed themes – Oncology, Mental Health and Public Health – two of them chose the Mental Health track and presented T4, a revolutionary software aiming to improve communication for people suffering from a neurological trauma with their surrounding, while the five others chose the Oncology track. Within this track, one formed a team with other participants to work on DOConnect, an online platform that assists tumor boards with better suggestions for patients using power of AI and patient data points. Finally, the four others built a team together to develop Comf’Hair, the innovative accessory to reduce the psychological impacts associated to chemotherapy. We are glad to announce that this very last team won the Deeptech Prize and will enter a four-month program in order to develop their project!

MIT Hacking medicine, Paris, June 21-23, 2019

We are participating in MIT Grand Hack held in Paris this week-end (June 21st to June 23rd). We will have 48h to think about Innovative Solutions in Healthcare regarding one of the three main subjects proposed: Oncology, Mental Health and Public Health.

Let’s wish them Good Luck and stay tuned for a complete feed-back next week!

A month of immersion in the company Advanced Solutions: manufacturer of our 6-axis robotic arm!

Advanced Solutions Life Sciences is dedicated to the discovery, design, and development of integrated software and hardware solutions for the fields of science.

We went to Advanced Solutions to learn more about the Tissue Structure Information Modeling (TSIM®) software and the BioAssemblyBot® 3D printer in order to improve our 3D bioprinting proficiency.

The 3d.FAB platform is proud to announce his new partnership with Rheolution

Rheolution is a Canadian society specialized in viscoelastic characterization of (bio)materials, using a non-destrutive, contactless and cost-effective method. Starting in September 2018, the ElastoSensTM Bio² mechanical tester (http://www.rheolution.com/elastosens-bio2.html) will be at 3d.FAB in order to understand the rheological properties progression of 3d printed (bio)objects. An exclusive opportunity for our network to test the capability of ElastoSensTM Bio² to take on their challenges.

 

Rheolution website: http://www.rheolution.com/

 

For more information, please contact Edwin-Joffrey Courtial.